- Description of the dosage form
Ointment for external and local use: from white-yellow to yellow, with a characteristic smell of lanolin.
Gel for external and local use: opaque, gel-like mass of white with a grayish tint.
- Suppositories for rectal use: bullet-shaped from white-yellow to yellow. Heterogeneity of color in the form of inclusions or marbling is allowed. There is a funnel-shaped depression on the longitudinal section. The diameter of the suppository is no more than 10 mm.
- Pharmacological action
Pharmacological action – antiproliferative, immunomodulatory, antiviral.
Pharmacodynamics
Interferon alpha-2b human recombinant has antiviral, immunomodulatory, antiproliferative properties, suppresses the replication of RNA and DNA-containing viruses. The immunomodulatory properties of interferon alpha-2b, such as increased phagocytic activity of macrophages and increased specific cytotoxicity of lymphocytes to target cells, determine its mediated antibacterial activity.
In the presence of excipients included in the drug (including α-tocopherol acetate (all forms), citric, benzoic acids (gel), ascorbic acid (gel, suppositories), the specific antiviral activity of interferon alpha-2b increases, its immunomodulatory effect is enhanced (stimulation of the phagocytic function of neutrophils in the lesions), which allows to increase the effectiveness of the body’s own immune response to pathogenic microorganisms. In the presence of ascorbic acid (suppositories) and α-tocopherol acetate (all forms), the specific antiviral activity of interferon alpha-2b increases, its immunomodulatory effect is enhanced, which allows to increase the effectiveness of the body’s own immune response to pathogenic microorganisms. When using the drug, the level of secretory IgA increases, the level of IgE is normalized, the functioning of the endogenous interferon alpha-2b system is restored. Ascorbic acid and α-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It has been established that when using VIFERON®, there are no side effects that occur with parenteral administration of interferon alpha-2b preparations, and antibodies that neutralize the antiviral activity of interferon alpha-2b are not formed. The use of VIFERON® as part of complex therapy allows for a reduction in therapeutic doses of antibacterial and hormonal drugs, as well as a reduction in the toxic effects of the specified therapy.
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