Like all medicines, this medicine can cause side effects, although not everybody gets them.
Common (1 to 10 patients in 100):
headaches and dizziness,
nausea, vomiting, diarrhea, abdominal pain,
fatigue, fever,
itching, rash (appearing also after exposure to the sun),
Uncommon (1 to 10 patients out of 1000):
skin reactions: urticaria, hair loss.
Rare (1 to 10 patients in 10,000):
increased urea and creatinine in the blood, transient increase in bilirubin and liver enzymes in the blood,
shortness of breath, angioedema (swelling of the soft tissues of the face, lips, tongue, sometimes with simultaneous swelling of the larynx, which can make breathing difficult),
anaphylactic reaction (potentially life-threatening hypersensitivity reaction with symptoms such as itching, hives, shortness of breath, drop in blood pressure, heart palpitations) – if you experience these symptoms, contact your doctor immediately.
Very rare (less than 1 patient in 10,000):
acute renal failure,
hepatitis, jaundice,
anemia, decreased white blood cell count, thrombocytopenia (absence of platelets in the blood),
agitation, confusion, tremor, clumsiness, slurred speech, hallucinations, psychotic symptoms, seizures, drowsiness, encephalopathy (brain damage), coma.
The package contains 30 tablets.
Before use, read the package leaflet for indications, contraindications, side effects, dosages and information about the use of the medicine, or consult a doctor or pharmacist, as any medicine used off-label can threaten your life or health .
1 tablet contains:
active substance: 200 mg of acyclovir (Aciclovirum)
excipients: lactose monohydrate, microcrystalline cellulose, povidone K30, sodium carboxymethyl starch type A, magnesium stearate.
Treatment of recurrent herpes:
lips and face caused by the herpes simplex virus in adults.
external genitalia caused by the herpes simplex virus in adults.
Invirum should only be used in patients who have had a herpes simplex infection in the past.
Keep the medicine out of the reach of children.
Store below 25˚C.
Do not dispose of the medicine in the sewer or household waste.
It is advisable to ask your pharmacist how to throw away medicines that you no longer use. This behavior will help protect the environment.
Do not use in children and adolescents under 18 years of age.
Do not take in case of hypersensitivity to acyclovir, valaciclovir or any of the excipients.
Do not use Invirum without first consulting your doctor:
in patients with impaired renal function;
in patients with renal insufficiency, especially with dehydration, taking high doses of acyclovir or other drugs that can damage the kidneys;
in elderly patients;
in pregnant or lactating women;
in people with a weakened immune system (for example, after bone marrow transplantation, HIV-infected).
No significant interactions with other drugs were found.
Tell your doctor or pharmacist about all medicines you are taking, have recently taken or plan to use.
Simultaneous ingestion of food does not affect the absorption of Invirum (it can be taken simultaneously with meals or separately).
Drink plenty of fluids while taking high doses of acyclovir.
Drink plenty of fluids when taking high doses of acyclovir to avoid kidney damage.
Caution should be exercised when using the drug in patients with impaired renal function.
Immunocompromised people should see a doctor about treating any infection:
in patients who have developed particularly severe recurrent herpes,
in patients who have developed particularly severe recurrent genital herpes,
in case of detection of frequent (> 6 per year) and longer (lack of a positive effect of treatment after 5 days of therapy) than before, herpes recurrences, with more pronounced clinical symptoms (for example, when new foci of infection appear after 3-4 days of therapy ). This may indicate immunodeficiency or malabsorption, requiring diagnosis and the need for a different dosage of the drug.
Pregnancy, breastfeeding and fertility
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, check with your doctor before taking this medicine.
The use of Invirum during pregnancy should be avoided unless the physician considers that the benefit to the mother outweighs the potential risk to the fetus.
The drug is excreted in breast milk, so care should be taken when using during breastfeeding. In the future, the drug can be used only after consulting a doctor.
Driving and using cars
There is no data on the effect of the drug on the ability to drive a car and work with mechanisms.
However, the possibility of side effects of acyclovir (eg, dizziness, confusion, convulsions) should be taken into account.
Invirum contains lactose monohydrate. If
your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Taking more than the recommended dose of the drug
Acyclovir is only partially absorbed from the gastrointestinal tract. A single dose of acyclovir up to 20 g usually does not cause toxicity.
Accidental repeated overdose of oral acyclovir within 7 days has been associated with gastrointestinal symptoms (nausea, vomiting) and neurological symptoms (headache, confusion).
If you have taken more than the recommended dose, contact your doctor or pharmacist immediately.
Adults: 200 mg 5 times a day every 4 hours (with a night break) for 5 days.
For recurrent infections, it is especially important to start treatment in the prodromal period (prodromal symptoms, such as burning, itching) or immediately after the first rash appears.
Patients with severe renal insufficiency (creatinine clearance less than 10 ml / min): the decision on the dosing method is made only by the doctor, who can reduce the dose to 1 tablet (200 mg) 2 times a day approximately every 12 hours.
Elderly patients: The possibility of renal failure should be considered.
Drink plenty of fluids during treatment.
If you don’t feel better or feel worse after 5 days, see your doctor.
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