Action
The active substance in Amertil tablets is cetirizine, which is a second-generation antihistamine drug with a strong and long-lasting effect. It is a selective histamine H1 receptor antagonist. It has no affinity for cholinergic and serotonergic receptors and does not penetrate the blood-brain barrier, therefore it is devoid of adverse sedative properties.
It counteracts the allergic reaction in its early phase, and also inhibits the migration of eosinophilic cells and reduces the release of mediators of the late phase of the allergic reaction. When taken orally, cetirizine is rapidly and completely absorbed, reaching a maximum blood concentration in approximately 60 minutes. Food does not affect the amount absorbed. About 93% binds to plasma proteins. The mean half-life of cetirizine is about 8 hours in adults and about 7 hours in children. It is excreted unchanged within a few days, mainly in the urine.
Dosage
Adults and children over 12 years of age are usually prescribed 10 mg (1 tablet) per day, preferably in the evening.
In children from 6 to 12 years old, the drug is used depending on body weight.
Children weighing more than 30 kg are prescribed 10 mg (1 tablet) 1 time per day, and children weighing less than 30 kg – 5 mg (1/2 tablet) 1 time per day.
People who are especially sensitive to the action of the drug, and children, the recommended dose can be administered in two divided doses every 12 hours. Do not increase the recommended dose without consulting your doctor.
The writing
Active substance: cetirizine dihydrochloride 10 mg.
Excipients: lactose, microcrystalline cellulose, modified starch, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, polyethylene glycol.
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